Archives
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Increasing age among middle aged subjects years old
2020-11-27
Increasing age among middle-aged subjects (30–59years old) was associated with higher levels of cholesterol synthesis markers (although without statistical significance) and also of cholesterol Cy5 EGFP australia markers (with statistical significance for campesterol and sitosterol); this finding is
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Mouse FGF21 / Fibroblast Growth Factor 21 Protein (His Tag)
2020-11-27
Discussion Of the age-related differences in serum non-cholesterol sterols, we first deal with the cholesterol precursors. After birth, the markedly elevated serum desmosterol values decreased during the first year of life, and after 1 year of age they were similar between the other age groups. S
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br Acknowledgements br Introduction Water and
2020-11-27
Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and Caspase-10/b, human recombinant protein governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the importance of ch
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AON successfully alleviated the myotonic phenotype
2020-11-27
AON successfully alleviated the myotonic phenotype in DM model mice [18], [23]. To screen for an optimal AON sequence, we used 25-mer phosphorothioate 2′ O-methyl RNA molecules that covered the exon 6B or exon 7A. Unexpectedly, AON 7A (+63−8) which covers the boundary of intron 7A and exon 7A enhan
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The new ESC guidelines incorporate data from a
2020-11-27
The new ESC guidelines incorporate data from a network meta-analysis of 100 studies confirming that new-generation drug-eluting stents (DES) improve survival compared with medical treatment, although this has not been demonstrated in any individual study. REVASCULARIZATION IN NON–ST-ELEVATION ACU
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4a 5 2 3.25 a In summary we have identified a series of
2020-11-27
In summary, we have identified a series of amides as ERRγ agonists with suitable potency for further development. Our SAR studies of this chemotype identified SR19881 as the most potent full agonist of ERRγ with an EC=0.39 μM in a binding assay and an EC=4.7 μM in a cell-based assay. SR19881 was als
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Compression The L vertebral body was tested in compression
2020-11-27
Compression: The L4 vertebral body was tested in compression with loads applied along the craniocaudal axis using an Instron 8800 device at a rate of 3mm/min. Load displacement data were captured using Bluehill software. The ultimate load, yield load, stiffness, ultimate stress, yield stress and You
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NPS-2143 Introduction Enzymes have higher selectivity specif
2020-11-27
Introduction Enzymes have higher selectivity, specificity and efficiency than chemical catalysts. Due to their properties and their green chemistry, biocatalysts are widely used in food, textile and pharmaceutical industry [1], [2]. A high efficient biocatalyst for industrial applications must be s
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br Conclusions Enzyme prodrug therapy mediated by implantabl
2020-11-27
Conclusions Enzyme prodrug therapy mediated by implantable biomaterials combines the benefits offered by the site specific drug delivery techniques and the systemic administration of drugs. From the former, SMEPT inherits the localized mode of drug delivery with lower systemic distribution of the
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Using the juxtarenal PPE the induction of
2020-11-27
Using the juxtarenal PPE, the induction of juxta- and suprarenal aneurysms is described herein (Fig. 3A). The infra-/suprarenal part of the BRL 37344, sodium salt synthesis can now be investigated separately, taking into account different embryological backgrounds and varying reactivity to differin
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In conclusion using human liver microsomes supersomes from
2020-11-27
In conclusion, using human liver microsomes, supersomes from baculovirus-transformed insect cells expressing different human CYP450 isoforms, and V79MZh3A4 cells, MB2 and MB4 were formed from TRB and MC from TRC. The amounts of MB2, MB4, and MC formed were related to the 6β-testosterone hydroxylase
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br Results br Discussion CCA
2020-11-27
Results Discussion CCA is a fatal tumor originating from the intrahepatic bile duct and the prognosis is very poor (Hoyos et al., 2018). CCA is one of the most dangerous primary liver malignant tumors and the most common malignant tumor of the biliary tract worldwide. However, the underlying m
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br Experimental Procedures br Author Contributions
2020-11-27
Experimental Procedures Author Contributions Acknowledgments Introduction Oxysterols came to prominence in the late 1970's with the oxysterol hypothesis which proposed that the suppressive effect of cholesterol on its own synthesis is mediated through oxysterols not by cholesterol itsel
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br Oxysterols as Key Players
2020-11-27
Oxysterols as Key Players in Metabolic Syndrome? Obesity and sedentary lifestyle are on the rise and pose serious threats to people's health and wellbeing. Obesity is often associated with other pathologies and is one of the criteria included in the definition of metabolic syndrome (MetS) (see Gl
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In mice our EBI EGFP reporter showed that
2020-11-27
In mice, our EBI2EGFP reporter showed that EBI2 is expressed consistently in naive T helper cells. Already single positive CD4+ thymocytes express EBI2 (not shown). In effector and regulatory T cells in naive mice, the percentage of EBI2 expression was lower (∼40%). Like others (Liu et al., 2011), w