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Pyrene azide 3 In addition to Rabs several proteins have bee
2022-07-02
In addition to Rabs, several proteins have been shown to interact with Rabphilin3a, for instance the GluN2A subunit of the NMDA receptor, PSD-95 ([56,57] and references therein), Rabaptin-5, α-actinin [16] and SNAP-25 [21,23,41,61]. Only the latter has been reported to participate in the AR. Explori
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In this study we evaluated and compared the kinetics and
2022-07-02
In this study we evaluated and compared the kinetics and duration of the oral and systemic HPV-16 and HPV-18 specific antibody response to three doses of the qHPV vaccine in mid-adult aged HIV+ men from the AIDS Malignancy Cohort (AMC) 052 trial and mid-adult aged HIV− men from the Mid-Adult Male [M
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The following are the supplementary data related to this art
2022-07-01
The following are the supplementary data related to this article. Transparency document Introduction Hypoxia is a pathological process that causes abnormal changes in metabolism, function and morphological structure of tissue because of insufficient oxygen supply. It's reported that hypoxia w
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Metallothioneins MTs that are intracellular proteins respons
2022-07-01
Metallothioneins (MTs) that are intracellular proteins responsible for the maintenance of metal homeostasis are involved in arsenic toxicity (Kita et al., 2006). Four major MT isoforms have been reported so far, MT1, MT2A, MT3 and MT4. The synthesis of MT1 and MT2A isoforms in mammal cells can be in
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Here we investigate the structural and biochemical propertie
2022-07-01
Here we investigate the structural and biochemical properties of the N-GTPase domain of p190RhoGAP-A. We determine the crystal structure and find that N-GTPase adopts an extended GTPase-like fold with six unique inserts that seem to preclude its ability to bind typical GAP, GEF, or Resiniferatoxin
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Bioinformatic analysis revealed a putative coiled coil SLD w
2022-07-01
Bioinformatic analysis revealed a putative coiled-coil SLD within CT229 which we show to be essential for intracellular replication and recruitment of Rab GTPases to the inclusion. Mutation of a single amino glucagon receptor residue in the SLD domain (CT229L120D) significantly reduced Rab binding
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Several studies have proposed that high levels of KYNA
2022-07-01
Several studies have proposed that high levels of KYNA in the Melatonin contribute to cognitive dysfunctions presented by patients who suffer from schizophrenia [30], [31], [32], [33]. Considering that: (i) KYNA is a known GPR35 agonist [2], (ii) cognitive impairments in patients with schizophrenia
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Azithromycin Dihydrate In recent large clinical studies AIM
2022-07-01
In recent large clinical studies, AIM-HIGH and HPS2-THRIVE, the additional treatment of nicotinic Azithromycin Dihydrate to statin-based LDL-C lowering therapy did not decrease the major vascular events on the patients who had atherosclerotic vascular diseases [43,44]. In the AIM-HIGH study, the sec
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br The glycine transporter GlyT was originally identified
2022-07-01
The glycine transporter 1 (GlyT1) was originally identified as a member of the solute carrier family 6 of sodium- and chloride-dependent neurotransmitter transporters . GlyT1 is expressed in the central nervous system and in peripheral tissues; mainly in erythroid cells, from erythroblasts in the
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Elimination of the Q R bridge significantly affected the
2022-07-01
Elimination of the Q234–R244 bridge significantly affected the protein blz but had little effect on its activity at a permissive temperature, which may seem contrary to the known functional importance of this motif in Fpg. However, since the mutants fully or partially retained the bound zinc (Table
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Ubiquitination of GlyRs subunit on
2022-07-01
Ubiquitination of GlyRs-α1 subunit on plasma membrane has been shown to initiate the receptor bradykinin receptor antagonist and subsequent degradation in lysosomes (Buttner et al., 2001). However, the specific E3 ligase responsible for GlyRs-α1 ubiquitination is largely unknown as yet. Also, the f
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br Acknowledgments This work was financially supported by
2022-07-01
Acknowledgments This work was financially supported by the National Natural Science Foundation of China (No. 81703451) and the China Postdoctoral Science Foundation Grant (No. 2017M611269). Introduction According to the International League Against Epilepsy (ILAE), epilepsy is generally defin
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Expression and translocation of GLUT are regulated by variou
2022-07-01
Expression and translocation of GLUT4 are regulated by various mechanisms including protein kinase C isoforms (PKCs) and mitogen-activated protein kinase (MAPK) signals [22], [23], but the real mechanism that statins alter expression and function of GLUT4 has not been fully identified. It is general
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br Introduction HH GLI signaling
2022-07-01
Introduction HH-GLI signaling is one of the major pathways involved in both normal and neoplastic development [[1], [2], [3], [4]]. Inappropriate activation of this pathway has been linked to cancer, including medulloblastoma, rhabdomyosarcoma, basal cell carcinoma and cancers of the lung, stomac
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The intestinal epithelium is the
2022-06-30
The intestinal epithelium is the first line of defense against pathogens and noxious agents and exerts a range of physiological activities, including digestion and Adenine australia of nutrients. The intestinal wall consists of a series of finger shaped protrusions called villi and invaginations kn
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