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br Lysophosphatidylinositol LPI LPI is
2022-03-21
Lysophosphatidylinositol (LPI) LPI is a subspecies of lysophospholipid consisting of inositol as its head group, one glycerol molecule and one acyl chain (Piñeiro and Falasca, 2012). The biosynthesis of this lipid starts from Phosphatidylinositol (PI) and is catalysed by the enzymes phospholipase
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br Materials and methods br Results br Discussion and
2022-03-21
Materials and methods Results Discussion and conclusions Our data demonstrate that native and 2-OMe-LPC analogues are GPR119 ligands and activate insulin secretion from βTC-3 pancreatic cells. LPC 18:1 was the first proposed endogenous ligand for GPR119 [1], however natural LPC has limited
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Extending the issue of the
2022-03-21
Extending the issue of the species differences, the role of neuroestradiol in the preovulatory GnRH/LH surge might be specific to primates or species with a luteal phase. For example, animals with a true luteal phase, such as monkeys and sheep, exhibit a long preovulatory GnRH surge, lasting well af
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After brain injury adenosine levels
2022-03-21
After brain injury, adenosine levels rapidly increase in the brain [9,10]. As shown in our previous studies, the increased adenosine concentration acts on adenosine A2A receptors (A2ARs), increasing post-traumatic glutamate levels in the brain and exacerbating the severity of injuries [11,12]. Accor
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br Regulation of Glu transporters The pivotal
2022-03-21
Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino ion channel calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include transcrip
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Ionotropic glutamate receptors GluRs are ligand gated ion
2022-03-21
Ionotropic glutamate receptors (GluRs) are ligand-gated ion channels that mediate information processing at the majority of excitatory synapses in the brain and participate in such physiological processes as learning and memory, development and maintenance of cellular connections, and pain perceptio
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The rapid actions of glucocorticoids range from the producti
2022-03-21
The rapid actions of glucocorticoids range from the production of endocannabinoid as a retrograde messenger [9], to regulation of ion channels [10], [11], to inhibitory effects on immune RI-1 [12], [13], [14]. Many different kinase signaling pathways have been implicated in the rapid actions of glu
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So in this study our results firstly demonstrated that i
2022-03-21
So in this Ipratropium Bromide receptor study, our results firstly demonstrated that i.c.v. injection of ghrelin(1–7)-NH2 played a significant role in the modulation of the acute heat pain at the supraspinal level in mice. Our results showed that i.c.v. injection of ghrelin(1–7)-NH2 produced dose- a
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To understand the impact of alterations in brain zinc
2022-03-21
To understand the impact of alterations in PD 169316 mg zinc homeostasis, the role of Zn2+ as a neurotransmitter has to be appreciated. Certain regions of the brain including the neocortex and hippocampus harbour so-called “zincergic” (or “gluzinergic”) neurons, where Zn2+ is co-released with gluta
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Magtanong et al observed that caspase dependent apoptotic
2022-03-18
Magtanong et al. (2019) observed that caspase-dependent apoptotic lipotoxicity of saturated fatty acids is suppressed by exogenous MUFAs. This may explain the ability of MUFAs to prevent atherosclerosis, in contrast to the pathogenicity of saturated fatty acids. Moreover, MUFAs may promote while PUF
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Over the years a number of studies
2022-03-18
Over the years, a number of studies have reported results concerning the behavior of the two endothelin receptor subtypes, ETA and ETB, that do not fit the classical model of two G protein-coupled receptors acting independently of one another. For example, in the rat anterior pituitary gland, both E
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Zoniporide dihydrochloride The molecular mechanism of gliotr
2022-03-18
The molecular mechanism of gliotransmitter release is not fully understood until now, and previous studies have emphasized that the elevation of [Ca2+]i triggers vesicular Zoniporide dihydrochloride of glutamate. Parpura et al. reported that the essential role of Ca2+ release from internal stores i
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GSK dimethylpiperidin yl butoxy phenyl piperidine carbonyl n
2022-03-18
GSK-835726 (3-[4-[4-[4-[4-(3,3-dimethylpiperidin-1-yl)butoxy]phenyl]piperidine-1-carbonyl]naphthalen-1-yl]propanoic acid) is a dual H1/H3 receptor antagonist with the potential to be used in allergic rhinitis. Likewise GSK-1004723, the drug-likeness criteria have not been passed by this drug candida
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The HCV Ag immunoassay has been shown from
2022-03-18
The HCV-Ag immunoassay has been shown from previous studies to be an adequate alternative to the two-stage diagnostic process [6], [9], [16]. Kesli et al. reported a high correlation coefficient of 0.864 when comparing HCV core antigen levels with HCV RNA levels (detected using Qiagen HCV RNA test;
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The PAS and CC domains of
2022-03-18
The PAS and CC domains of sGC have been studied less by comparison, though their function in sGC signal transduction is likely important. PAS domains are versatile as they can play varied roles in different proteins, such as quaternary structure organization, cofactor binding, and signal transductio
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