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XMD17-109 Notably Cu labeled dimeric exendin subunit which w
2021-11-19
Notably, 64Cu-labeled dimeric exendin-4 subunit, which was designated as 64Cu-Mal2Sar-(exendin-4)2, showed higher tumor uptake than that of the monomeric exendin-4 subunit [245]. Besides the most commonly-used GLP-1R agonists exendin-3 and -4 and their derivatives, exendin (9-39) exhibits strong bin
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Similar to GPR A activation of G protein
2021-11-19
Similar to GPR109A, activation of G-protein-coupled receptor 81 (GPR81, also called HCAR1 (hydroxycarboxylic Annexin V-Cy3 Apoptosis Kit Plus synthesis receptor 1)) by lactate suppresses lipolysis (Fig. 1), suggesting GPR81 to be a potential drug target for treating T2DM (Boyd et al., 1974, Cai et
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The Berlin patient is a unique
2021-11-19
The Berlin patient is a unique case and dependent on the histocompatibility-matched CCR5Δ32/Δ32 homozygous donors. These donors occur at a little higher rate in the European Caucasian population, but they are very rare in Asians and Africans.15, 16, 17 The recently developed genome-editing technolog
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GSK3787 IBs had a clear vesicular ultrastructure suggesting
2021-11-19
IBs had a clear vesicular ultrastructure, suggesting that a large part of the iron-containing mitochondrial remnants might be cleared via normal autophagy processes during final reticulocyte maturation [21]. IB formation was followed by characteristic changes in RBC morphology, with irregularly shap
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Hesperidin is an abundant and inexpensive plant flavonoid
2021-11-19
Hesperidin is an abundant and inexpensive plant flavonoid, largely derived from citrus species including sweet orange and lemon. Hesperetin (Hst) is the aglycone of hesperidin. Hesperidin and hesperetin have been reported to show a battery of pharmacological properties, including anti-hyperlipidemic
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The inhibition of NSAIDs towards
2021-11-19
The inhibition of NSAIDs towards GLOI provides a direction for the development of novel effective GLOI inhibitors. Although the inhibitory activity of indomethacin was determined and the interactions between it Nicotinamide and GLOI were probed by NMR titration experiments, no detailed inhibitory m
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Hippocampal lesioned mice were less able to withhold respond
2021-11-18
Hippocampal-lesioned mice were less able to withhold responding during a DRL-10 requirement (i.e. when the animals had to wait 10s between lever presses), and were thus less efficient than sham operated controls. In contrast, GluR-A−/− mice did not differ from wild-type mice when the DRL requirement
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In the last thirty years accumulating data have
2021-11-18
In the last thirty years, accumulating data have addressed a role for GABA in the modulation of gastrointestinal (GI) functions via its possible involvement in the circuitry of the enteric nervous system (ENS). The ENS is a complex neuronal network located within the gut wall, capable of regulating,
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br Promotion of GLS expression Glutamine metabolism is anoth
2021-11-18
Promotion of GLS2 expression Glutamine metabolism is another target for alteration in ferroptosis. Glutamine is required for the induction of ferroptosis during serum-induced injury after amino 3-Cyano-7-ethoxycoumarin starvation [72]. The first step of glutamine catabolism is its conversion to
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The investigation in vitro revealed
2021-11-18
The investigation in vitro revealed that aldolase, as well as FBPase, has affinity to α-actinin, one of the structural protein of the Z-line (Rakus et al., 2003a, Mamczur et al., 2005). Therefore, the existence of in vivo heterologous complex, consisting of aldolase, FBPase and α-actinin has been po
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monooxygenase br Material and methods br
2021-11-18
Material and methods Results Discussion It is challenging to discriminate between HIV monoinfection and HIV-1/2 dual infection in settings where both viruses co-exist, due to cross-reactivity in serological tests. Thus, the gold standard for detection of HIV-1/2 dual infection is through NA
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Based on the aforementioned findings
2021-11-18
Based on the aforementioned findings, variations of the imidazole heterocycle present in the endogenous ligand histamine (1) led to 2-(thiazol-2-yl)ethanamine (2-TEA, 2) and later to 2-(3-bromophenyl)histamine or 2-(3-(trifluoromethyl)phenyl)histamine (3) (Fig. 3). Interestingly, 2-TEA demonstrated
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W123 sale One limitation of our study was that all control d
2021-11-18
One limitation of our study was that all control dogs had histologic evidence of mild GI inflammation according to established WSAVA guidelines (Washabau et al., 2010), despite being apparently healthy purpose-bred research dogs housed in a controlled environment with no history of vomiting, diarrhe
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mefloquine hcl With LML methyl oxo dihydropyridazin yl piper
2021-11-18
With LML-134 (1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)piperidin-4-yl 4-cyclobutylpiperazine-1-carboxylate) containing drug-likeness properties (MW 375.47, five HBA, and MLogP 1.88), Novartis presents an additional drug-candidate to treat excessive sleepiness. A phase I clinical study was perform
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Nowadays it is accepted that
2021-11-18
Nowadays, it is accepted that ligands which have been classically described as inverse agonists, due to their negative efficacy at modulating the G protein pathway, could also display some positive efficacy regarding receptor desensitization, internalization, or even signaling though another pathway
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