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br Making the BN Cox model
2021-03-29
Making the BN-Cox model computationally efficient One of the challenges to applying the BN-Cox model is an exponential growth of the conditional probability tables (CPT) corresponding to the survival variables, as the number of risk factors increases [22]. When the number of risk factors is high
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Dopamine activity in the PFC and
2021-03-29
Dopamine activity in the PFC and striatum may be antagonistic, meaning that lower levels of dopamine in the striatum tend to correspond to higher levels of dopamine in the PFC and vice versa (Cools and D'Esposito, 2011; Tunbridge et al., 2006). Human PET studies have reported that dopaminergic PFC f
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Does hydroxylation of proline have a specific role in the
2021-03-29
Does hydroxylation of proline have a specific role in the structure and function of the conotoxins? Several studies in the literature provide insights into the role of proline hydroxylation in the Conus peptides. The consequences of proline hydroxylation on oxidative folding and biological activity
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We have previously reported that CK is downregulated in sene
2021-03-29
We have previously reported that CK2 is downregulated in senescent human lung fibroblast IMR-90 cells, aged rat tissues, and aging nematodes [17,18]. CK2 downregulation induces cellular senescence via the PI3K-AKT-mTOR-reactive oxygen species-p53-p21Cip1/WAF1 pathway in human cells [[19], [20], [21]
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These data indicate that in the context of the
2021-03-29
These data indicate that, in the context of the N-terminal 42 amino acids of p53, threonine 18 is a substrate for phosphorylation by CK1 as mediated by prior phosphorylation of serine 15. To determine whether this is a property of full length p53, GST-p53 fusion proteins comprising the full length p
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In summary we show that PE significantly ameliorate
2021-03-29
In summary, we show that PE significantly ameliorate HCD-induced atherosclerosis in apoE−/− mice. Dietary fiber may influence the intestinal microbiota and thus the circulating levels of SCFAs. SCFAs, such as butyrate, inhibit cholesterol uptake and promote cholesterol excretion from enterocytes. Ou
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Ten non FH ADH probands fulfilled the diagnostic criteria of
2021-03-29
Ten non-FH ADH probands fulfilled the diagnostic criteria of hyperabsorbers. Table 2 shows the main lipid characteristics of these subjects and of 10 non-hyperabsorber probands used for comparison. There were differences between groups in body mass index, waist circumference and triglycerides. Othe
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Role of ROS signaling in regulating cell
2021-03-29
Role of ROS signaling in regulating cell death pathways has been well established. Involvement of CLIC1 in ROS production has been studied earlier. It was observed that macrophages from clic1 mice showed ~30% decrease in cellular ROS generation which effects macrophage function (Jiang et al., 2012).
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The modes of action of insecticides
2021-03-29
The modes of action of insecticides are classified by the Insecticide Resistance Action Committee (IRAC) [6]. In this classification, a large proportion of insecticides are categorized as nerve- and muscle-targeting insecticides, which encompass GABACl antagonists (Group 2) and GluCl allosteric modu
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The upregulation of PTGS and PTGS
2021-03-29
The upregulation of PTGS1 and PTGS2 in late gestation in mares could be linked to the high levels of estrogens produced by the fetoplacental unit. Estrogens are thought to be effective stimulators of prostaglandin production by potentially up regulating PTGS2 expression. Although a recent publicatio
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Bexarotene sale Early tubular differentiation in WT lacks lu
2021-03-29
Early tubular differentiation in WT lacks lumen formation and, therefore, sometimes can be confused with rosettes of ES/PNET or neuroblastoma. However, tubular structure usually has Bexarotene sale neatly aligned to form a single layer around the future lumen, whereas neuroblastic rosettes are arra
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A major finding to emerge from this
2021-03-29
A major finding to emerge from this study is a conserved regulatory scheme deployed by both innate and adaptive lymphocytes, which is coordinated by a cohort of TFs. The scheme functionally compartmentalizes effector tandospirone sale that circulate between blood and peripheral tissues from self-ren
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br Conflicts of interest br Acknowledgements
2021-03-27
Conflicts of interest Acknowledgements Introduction Atherosclerosis is the number one cause of death in the United States and among the leading causes of morbidity and mortality globally [1]. Inflammation is critical in all stages of atherosclerosis from the formation of a plaque in the ves
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Support for Cloninger s personality theory comes also from
2021-03-27
Support for Cloninger's personality theory comes also from molecular genetic studies. Given the high heritability of personality it is plausible that gene variants explain variance in RD. In Daidzein to endocrine studies, which relate hormone levels mostly in the periphery (blood, saliva, urine) to
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Poxviruses have double stranded DNA dsDNA genomes yet they
2021-03-27
Poxviruses have double-stranded DNA (dsDNA) genomes, yet they replicate within the cytoplasm. Poxviruses that cause human disease include monkeypox virus (Reynolds et al., 2004), molluscum contagiosum virus (Hanson and Diven, 2003) and variola virus (VARV), the cause of smallpox, a disease eradicate
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