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WYE-125132 Curcumin is a polyphenol extracted from
2020-03-26
Curcumin is a polyphenol extracted from turmeric, which is commonly used as a spice and food-coloring agent in many cultures [9]. Curcumin possesses anti-inflammatory, antioxidant, and cancer-preventive properties [10], [11], [12]. In addition to these well-known effects, consuming curcumin may bene
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The most common adverse events in
2020-03-26
The most common adverse events in relation to udenafil treatment are headache and facial flushing; other possible adverse events are febrile sensation, dyspepsia, and visual disturbances. No severe adverse event related to udenafil has been reported thus far. The adverse event rate recorded in the p
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bafilomycin a1 autophagy Recoverin is a kDa retinal protein
2020-03-26
Recoverin is a 23-kDa retinal protein that binds to calcium. It regulates the bafilomycin a1 autophagy of rhodopsin during visual transduction within photoreceptor cells. Since the pathogenicity of anti-recoverin antibody is potent, anti-recoverin CAR patients often have progressive visual impairme
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However in many of the above mentioned studies
2020-03-26
However, in many of the above mentioned studies, the NaCl concentrations in the extraction buffers were different from those used here. For instance, in the study that performed cathepsin D extraction from human AD lb100 tissue, the concentration was 150mM [30], while that for the extraction of the
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br The contribution of Interference RNA and epigenetic in
2020-03-26
The contribution of Interference RNA and epigenetic in OA attenuation Interference RNA, a cellular mechanism for post-transcriptional gene silencing that is associated with mRNA. The potential of RNAi has successfully silenced the wide range of protein coding genes. Its high specificity sanctions
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The monomeric oligomeric states of DDR V His
2020-03-26
The monomeric/oligomeric states of DDR2-V5-His and DDR2-Fc were confirmed by Western blotting under reducing and non-reducing conditions. As shown in Fig. 1b, DDR2-V5-His exhibited a relative molecular mass of ~60 kDa under both reducing and non-reducing conditions, consistent with this protein bein
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680C91 br Genomic actions in the breast br Conclusion Clinic
2020-03-26
Genomic actions in the breast Conclusion Clinical studies suggest that progesterone and/or progestins may play a decisive role in the development of breast cancer in women using hormone therapy or oral contraceptives [3], [4]. However, this data are controversial to most experimental investiga
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AMPHs facilitate dopamine release which further triggers
2020-03-25
AMPHs facilitate dopamine release, which further triggers dopamine depletion [72]. Indeed, we observed that repeated treatment of MPA significantly inhibited TH-, DAT-, and VMAT-2 levels. Since DAT and VMAT-2 are important for dopaminergic terminal markers [10], their decreases suggest that MPA-indu
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br Results To understand how Rad
2020-03-25
Results To understand how Rad53 functions to maintain replisome integrity, we first analyzed newly synthesized leading- and lagging-strand DNA in wild-type (WT) and rad53-1 mutant cells using BrdU-IP-ssSeq, a method that detects synthesis of both leading and lagging strands (Yu et al., 2014). Bri
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br Conclusion br Conflict of interest br
2020-03-25
Conclusion Conflict of interest Introduction The sexual exploitation and internal trafficking of British children within the UK has received growing public and policy attention in recent years. This has largely been in response to a number of high profile police investigations into cases in
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The identification of a functional leucine
2020-03-25
The identification of a functional leucine-rich NES mediating 8E7 nuclear export led us to analyze the interaction between 8E7 and CRM1 nuclear export receptor. HeLa cell lysates containing EGFP-8E7, EGFP–8cE7, EGFP-16E7–NES (as a positive control), or EGFP (as a negative control) were incubated wit
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Cholesterol homeostasis is maintained through a
2020-03-25
Cholesterol homeostasis is maintained through a tight regulation between endogenous de novo synthesis, dietary absorption, utilization and excretion of bile salts. The VU 0155069 of cholesterol from the intestine constitutes the central part of cholesterol homeostasis in the body [41]. In particular
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In humans the ER is encoded by the gene
2020-03-25
In humans, the ERα is encoded by the gene ESR1, located on chromosome 6, locus 6q25.1 (Gosden, Middleton, & Rout, 1986). In addition to the full-length ERα isoform (66kDa), several shorter isoforms (36kDa, 46kDa) have been identified as a result of the presence of alternate start codons, or as produ
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br Introduction Fibroblast growth factors FGF are
2020-03-25
Introduction Fibroblast growth factors (FGF) are a family of 18 secreted ligands that bind to four receptor tyrosine kinase (RTK) FGF receptors (FGFR1–4). The interaction of FGFs with their cognate receptors results in the activation of a number of downstream signaling pathways, including the MAP
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Amphiphilic compounds lower interfacial tension
2020-03-25
Amphiphilic compounds lower interfacial tension and its biological production often results in a competitive environmental advantage (Darvishi et al., 2011). The reduction of interfacial tension can increase the biologically available surface areas resulting in increased metabolism of insoluble comp
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