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Metabolic therapy has become trendy
2018-10-24
Metabolic therapy has become trendy in attenuating the side effects of glioma treatment (Schwartz et al., 2015; Zuccoli et al., 2010; Seyfried et al., 2015). This type of therapy is designed to disrupt tumor microenvironment, while enhancing the health and vitality of normal cells. It has been demon
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All iPSC derived neurons demonstrated expression of function
2018-10-24
All iPSC-derived neurons demonstrated expression of functional neurotransmitter receptors, responding to glutamate/glycine, GABA and to a lower extend to acetylcholine. Interestingly, the neuronal cultures also developed synchronized spontaneous calcium oscillations, which were likely to reflect Sun
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br Materials and methods br
2018-10-24
Materials and methods Acknowledgements This study was supported by the European Union within the 7th European Community Framework Programme through funding for the NEUROMICS network (F5-2012-305121 to L.S.), the Marie Curie International Outgoing Fellowship (grant PIOF-GA-2012-326681 to R.S. a
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br Materials and methods br Results br
2018-10-24
Materials and methods Results Discussion The effect of donor MSCs in tumor growth remains controversial (Cho et al., 2009). Discrepancies concerned to whether they promote or suppress it may be due to disparities in cell source, isolation and expansion conditions, via and timing of administ
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The majority of the characterized NETs bind
2018-10-24
The majority of the characterized NETs bind lamins and/or chromatin binding proteins (Harr et al., 2016; Kind et al., 2013; Wong et al., 2014). Chromatin proteins in pluripotent stem strontium chloride display hyperdynamic plasticity (Chen and Dent, 2014; Meshorer et al., 2006). During differentiati
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CSCs of breast tumors are commonly enriched by combinations
2018-10-24
CSCs of breast tumors are commonly enriched by combinations of several cell-surface antigens, such as CD44/CD24/EPCAM (Al-Hajj et al., 2003), or by high ALDH (aldehyde dehydrogenase) activity (Ginestier et al., 2007). However, existing markers lack specificity, also reflective of a substantial propo
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br Experimental Procedures br Author
2018-10-24
Experimental Procedures Author Contributions Acknowledgments The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreement n.602300 (SYBIL) to A.V., PRIN Project 20102M7T8X_003 to A.V., Ricerca Finalizzata from Min
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Main Text br Acknowledgments I have
2018-10-24
Main Text Acknowledgments I have been fortunate to work with tremendous mentors, colleagues, and students throughout my career and I am grateful for their past and current support. Research in my laboratory is supported by the NIH, the New York Stem Cell Foundation as a New York Stem Cell Founda
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FUS binds to DNA as well as to
2018-10-24
FUS binds to DNA as well as to RNA and regulates the expression of many transcripts in multiple steps of the gene regulation process (Dormann and Haass, 2013). In this study, we used FALS MPCs efficiently oriented into neuronal lineages including HB9-positive motor neurons to observe altered gene r
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br Acknowledgments The study is supported by funds to
2018-10-24
Acknowledgments The study is supported by funds to W-Q.G. from the Chinese Ministry of Science and Technology (2012CB966800, 2013CB945600, and 2012CB967903), the National Natural Science Foundation of China (81130038 and 81372189), the Science and Technology Commission of Shanghai Municipality (P
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Previous studies have reported that
2018-10-24
Previous studies have reported that Notch signaling controls the induction of neural stem cystic fibrosis chloride channel in vitro and in vivo during differentiation (Crawford and Roelink, 2007; Nelson et al., 2007). As established by Ogura et al. (2013), inhibition of this signaling pathway promo
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br Experimental Procedures br Author Contributions br Acknow
2018-10-24
Experimental Procedures Author Contributions Acknowledgments This work was supported by grants to W.H. from the National Natural Science Foundation of China (81372258, 81572827), the Major State Basic Research Development Program of China (2013CB910802), and the Program for Professor of Spe
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br Introduction Hearing loss is the most common congenital s
2018-10-24
Introduction Hearing loss is the most common congenital sensory deficit (Chan et al., 2010). Approximately 1 child in 1,000 is affected with severe hearing loss at birth or during early childhood, and this is defined as prelingual deafness (Morton, 1991; Petersen and Willems, 2006), with about ha
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bms-690514 Additional models were tested to assess the robus
2018-10-24
Additional models were tested to assess the robustness of the main results to the different specifications. These included whether having a history of bankruptcy prior to the age 40-health module influenced the overall results. None of the 370 women with a pre-40 health bankruptcy who were added, ho
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Otamixaban As above mentioned in both countries the Netherla
2018-10-24
As above-mentioned in both countries (the Netherlands and the Philippines), pride is an important driver of both sales performance and citizenship behaviors. Therefore it is important for managers to instill pride in their salesforce as it has broaden-and-build effects on other emotions (Fredrickson
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