• The numbers and types of

  2024-05-16

  

  The numbers and types of molecules needing to be transported across membranes are very large, and there is a corresponding very large and diverse number of transporters expressed throughout the body. Hundreds of proteins that have been assigned as having transporter function are broadly divided into

• br ABCA is a sterol responsive gene The first evidence

  2024-05-16

  

  ABCA2 is a sterol-responsive gene The first evidence to demonstrate that ABCA2 expression responded to sterol loading was provided in an experiment involving monocyte to macrophage differentiation in vitro. Upon sterol loading with enzymatically degraded LDL (eLDL), ABCA2 expression increased onl

• In addition we aimed to examine the possible

  2024-05-16

  

  In addition, we aimed to examine the possible role of adiponectin in modulating changes in IR. It was observed that there was a simultaneous decline in expression of IR and AdipoR1 proteins in the ovary of PCOS-mice as compared to the control ovary. Further, a strong correlation was found between ch

• Based on the observation that antipsychotic drugs

  2024-05-16

  

  Based on the observation that antipsychotic drugs increase 5-HT1A–D2 heteromerization level (Łukasiewicz et al., 2016), we set out to compare the effect of paroxetine to that of risperidone. Paroxetine, a potent SSRI, is very effective in the treatment of depression and anxiety disorders, e.g., gene

• To understand the kinase selectivity

  2024-05-15

  

  To understand the kinase selectivity profile of this series, PA452 , as a representative analog from this series, was profiled against 216 purified protein kinases representing the tyrosine and serine/threonine kinase families using an in-house Caliper EZ Reader mobility shift assay. Assays were con

• Introduction Myasthenia gravis MG is an autoimmune disorder

  2024-05-15

  

  Introduction Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle weakness, which is mainly due to autoantibodies reducing the number or function of postsynaptic RGFP966 receptors (AChRs) [1], [2]. Animal models have been developed to uncover the immunopathogenesis of MG. Experi

• The nAChR has been considered

  2024-05-15

  

  The α7 nAChR has been considered an interesting potential target for numerous therapeutic indications over the last two decades, with GTS-21 one of the first candidates proposed for Alzheimer's disease [2], [3], [23]. Unfortunately, although many α7-selective agonists have been developed [21], none

• The obtained results indicate that even when the

  2024-05-15

  

  The obtained results indicate that even when the impairment of the same forms of memory are present, amnesia can develop in different ways. Impairment of memory reconsolidation in the conditioned food aversion model through both the serotonin receptor antagonist and the antagonist of NMDA glutamate

• The role of DHT in

  2024-05-15

  

  The role of DHT in early teleost embryogenesis is not entirely clear or established, however additional studies that treat fish embryos to DHT or to specific srd5a inhibitors at critical stages of development (i.e. prior to sex differentiation) will shed light on the early functions of this androgen

• An AXL decoy receptor with

  2024-05-15

  

  An AXL decoy receptor with enhanced GAS6-binding properties, MYD1, was engineered as a therapeutic tool to disrupt GAS6/AXL signaling in vivo (Kariolis et al., 2014). MYD1 was shown to block metastasis of human ovarian cancer NVP 231 and a murine breast cancer cell line in grafting assays in mice.

• br Autophagy and cell death pathways in ischemic

  2024-05-15

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic Z-VDVAD-FMK synthesis injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great difference

• br Autophagy inducers Macroautophagy is often seen as a cell

  2024-05-15

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of Y-27632 and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective strategy for enhancing sensitivity of canc

• When skeletal muscle ages there is an increase in frailty

  2024-05-15

  

  When skeletal muscle ages, there is an increase in frailty, which is coincident with a decrease in muscle mass and function—this condition is called sarcopenia (Cruz-Jentoft et al., 2010). It has been shown that one of the major pathways downregulated at the onset of sarcopenia is the mitochondrial

• exemplifies three of the compounds investigated in

  2024-05-15

  

  exemplifies three of the compounds investigated in the selection for a candidate drug (CD). Our first criteria was an IC metabolic stability and poor pharmacokinetic properties. The triazole BLX-2477 () which had a decent IC in the cell assay (56nM) was more extensively investigated. Although it is

• Telomerase action at the telomere is highly regulated

  2024-05-15

  

  Telomerase action at the telomere is highly regulated; it preferentially elongates the shortest telomeres, and recruitment of the enzyme complex to the telomere occurs in mid-S phase of the cell cycle (Bianchi and Shore, 2007, Britt-Compton et al., 2009, Teixeira et al., 2004, Hemann et al., 2001, T

15094 records 100/1007 page Previous Next First page 上5页 96979899100 下5页 Last page