• Fermented dairy products contain adequate levels of

  2018-10-22

  

  Fermented dairy products contain adequate levels of certain live and active cultures, namely probiotics that aid to improve the balance of “beneficial” versus “undesirable” bacteria in the intestinal tract. Several researches on fermented dairy products showed their effect on the immune system, as w

• The conflicting findings of Jensen et al and Odunsi

  2018-10-22

  

  The conflicting findings of Jensen et al. [31,33] and Odunsi et al. [34] may be the result of different modes of alginate delivery. The greater volume of drinks compared to the volume of capsules may stimulate gastric stretch receptors, increase satiety and therefore reduce energy consumption. El K

• br Material and methods br Acknowledgments We are

  2018-10-22

  

  Material and methods Acknowledgments We are grateful to D. Trono (Lausanne, Switzerland) for the plasmid pMD2.G and psPAX2. We thank Brigitte Jenewein for her excellent technical assistance with the confocal laser-scanning microscopy and the flow cytometry analysis. This work was supported by

• Our results provide evidence that i transcription factor NF

  2018-10-22

  

  Our results provide evidence that (i) transcription factor NF-κB activation is necessary for limbal epithelial outgrowth on intact AM and MMP-9 expression (Fig. 4) and (ii) PI3-K/Akt and JNK pathways are involved in NF-κB activation (Figs. 5 and 6). Our data were supported by recent studies indicati

• The observation of context dependent expression of

  2018-10-22

  

  The observation of context-dependent expression of the potassium channels known to contribute to RMP may be interconnected to neuronal differentiation, maturation and viability. The resting potential of neuronal progenitors is typically depolarized (>−40mV) and gradually decreases with maturation (~

• Introduction The degree to which embryonic stem cells ESCs r

  2018-10-22

  

  Introduction The degree to which embryonic stem purchase BKM 120 (ESCs) represent generic properties of pluripotent founder cells in mammalian embryos is unresolved (Nichols and Smith, 2012; Smith, 2001). Mouse ESCs are the paradigmatic model. However, it is increasingly clear that there are differ

• Importantly using CXCL CXCR interactions as a

  2018-10-22

  

  Importantly using CXCL12/CXCR4 interactions as a paradigm for other factors and receptors, we demonstrated that CXCL12 is required for chemotaxis, but not chemokinesis of human UCB CD133+ HSPCs in the absence of niche elements, and that the CXCR4 antagonist, AMD3100, inhibits chemokine sensing but n

• br Introduction An area of growing

  2018-10-20

  

  Introduction An area of growing interest is to understand how extracellular matrix (ECM) and integrins cooperate within the stem cell niche to control the balance between renewal and differentiation. The biological relevance of ECM/integrin interactions in regulating cell functions and signaling

• To determine a profile of gene activation within the hearts

  2018-10-20

  

  To determine a profile of gene activation within the hearts of AMI rats following EXnaEFC administration, we performed a comprehensive PCR analysis of cardiac tissue seven days post-infarct and treatment. We reveal that the rats receiving EXnaEFCs exhibited rescued gene expression of Tnf, Sdf1 and C

• br Discussion In this study we obtained

  2018-10-20

  

  Discussion In this study, we obtained proof-of-concept data to support our hypothesis that AM can rescue OPC differentiation into mature oligodendrocytes under pathological conditions. Our pharmacological approaches also showed that the AM receptor and PI3K/Akt would mediate these AM effects. AM

• We developed our novel targeting technique in order to overc

  2018-10-20

  

  We developed our novel targeting technique in order to overcome one of the major problems with stem cell therapy, namely the high wash-out of injected stem EZ Cap Reagent AG (3\' OMe) by the blood and low engraftment rate. This high-washout of over 90% by the blood is irrespectively of the delivery

• The original XO karyotype Fig of the donor CVCs

  2018-10-20

  

  The original 45 XO karyotype (Fig. 1) of the donor CVCs was maintained in TS ViPSCs even after prolonged maintenance (passage 25) indicating that the process of reprogramming with episomal vectors and in vitro culture conditions did not alter this iPSC line chromosomally. The iPSC line established i

• The in vitro production and expression of

  2018-10-20

  

  The in vitro production and expression of ECM proteins collagens I and IV and laminin differed between the perivascular derivatives. In the body, pericytes produce ECM in the subendothelial basement membrane of capillaries, while both vSMCs and pericytes produce ECM in the tunica media layer of larg

• Our studies show that only a subpopulation of hESCs

  2018-10-20

  

  Our studies show that only a subpopulation of hESCs at the top of the hierarchy possesses an extensive capacity for self-renewal. Polanco et al. recently showed that metaformin in this compartment could reestablish the continuum of cell states seen in unfractionated cultures (Polanco et al., 2013).

• MSCs can express several WNT ligands Cho et al

  2018-10-20

  

  MSCs can express several WNT ligands (Cho et al., 2006; Etheridge et al., 2004). This endogenous WNT signaling may play a negligible role in MSC expansion, because we found no significant effects on cell proliferation or subsequent differentiation when endogenous WNT proteins were prevented. However

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