• Protein microarrays represent just one of a variety of exper

  2024-04-30

  

  Protein microarrays represent just one of a variety of experimental approaches that can be used to generate datasets of relevance to pathway mapping. Other approaches include protein YM155 profiling techniques, such as antibody arrays [29], tissue arrays [30] and 2-dimensional gel electrophoresis f

• Thus we presumed that ALDH A might play an

  2024-04-29

  

  Thus, we presumed that ALDH1A3 might play an important role in TMZ-chemoresistance in glioblastoma patients. As we expected, the glioblastoma cell lines and primary glioma BD 1047 dihydrobromide were more sensitive to TMZ treatment when ALDH1A3 was inhibited or depleted. Consistently, it has been s

• Lipotoxicity is the accumulation of excess lipids in

  2024-04-29

  

  Lipotoxicity is the accumulation of excess lipids in non-adipose tissues that leads to cell dysfunction or cell death. It may play an important role in the pathogenesis of diabetes, and contributes to the rate of progression of CKD [7,8]. Emerging evidence indicates that renal lipid dysregulation is

• In previous research we determined that blocking mAC during

  2024-04-29

  

  In previous research, we determined that blocking mAC during heparin-induced capacitation result in sperm having a lesser oxygen consumption, suggesting that cAMP produced by this enzyme would be linked to mitochondrial activity and, therefore, with the regulation of sperm metabolism (Fernández and

• br Methods and results ACE is a Canadian

  2024-04-29

  

  Methods and results ACE is a Canadian satellite mission [7] that measures atmospheric antisedan spectra in the limb geometry using the Sun as a light source (solar occultation). The ACE orbit (74° inclination to the equator, 650 km altitude) concentrates measurements at high latitudes but also p

• br lipoxygenase pathway in brain

  2024-04-29

  

  5-lipoxygenase pathway in alzheimer's disease aging and alzheimer’s disease 5LO is found throughout the central nervous system, in both neuron and glia cells (Farias et al., 2007). However, its expression levels are highest in the cortex and hippocampus areas, two regions that are particularly v

• br Role of autophagy in

  2024-04-29

  

  Role of autophagy in alcoholic cardiomyopathy Concluding remarks The genetic and phenotypic heterogeneity in alcoholic cardiac injury has been recognized despite the seemingly beneficial effects of low to moderate alcohol consumption [8]. Although oxidative stress is well established in the pa

• br Concluding remarks Autophagy ensures cell homeostasis

  2024-04-29

  

  Concluding remarks Autophagy ensures cell homeostasis and survival through the continuous degradation/recycling of intracellular components. It can also represent a conserved, cell-intrinsic, defense mechanism against invading pathogens, including viruses. The autophagy process can be activated r

• Because of the formation of phosphoenzyme intermediates

  2024-04-29

  

  Because of the formation of phosphoenzyme intermediates, the enzymatic 59 7 australia of P-ATPases can be divided into steps that include a kinase activity, by which an aspartate residue on the enzyme is phosphorylated, and a phosphatase activity, by which the phosphoenzyme is dephosphorylated. Ano

• The advantage of active immunotherapy is long term antibody

  2024-04-28

  

  The advantage of active immunotherapy is long-term antibody production from short-term drug administration at limited cost. Conversely, immune response may be inconsistent or lacking, especially in older individuals, and adverse reactions—if immunologically based—may also be long-lasting. Initial ex

• adenosine receptor antagonist A central question that arises

  2024-04-28

  

  A central question that arises in this discussion is whether enhanced neurobehavioral responses to food cues emerge as a consequence of weight gain, or whether there are intrinsic differences in the motivational responses to food cues that precede weight gain. In support of pre-existing differences,

• Further validation for a role in LOX pathway

  2024-04-28

  

  Further validation for a role in 12/15-LOX pathway in mediating adipocyte function comes from studies revealing a regulatory role of lipocalin-2 on 12/15-LOX activity. Lipocalin-2, a glycoprotein member of the lipocalin superfamily, is a novel abundant adipokine implicated in obesity-mediated inflam

• A number of interesting anti inflammatory molecules have als

  2024-04-28

  

  A number of interesting anti-inflammatory molecules have also been identified that are derived from AA or ω−3 fatty acids, including the lipoxins (for “lipoxygenase interaction products”), resolvins, and protectins [18], [19] (Fig. 1). The lipoxins are synthesized from AA by 5-, 12-, and 15-LOX, as

• br Acknowledgements br Introduction Diabetic complications a

  2024-04-28

  

  Acknowledgements Introduction Diabetic complications are responsible for increased morbidity and mortality of diabetic patients. Increased flow of trans-AUCB synthesis through the polyol pathway under conditions of hyperglycemia contributes to the development of diabetic complications. Aldose

• br Acknowledgements This work was supported by

  2024-04-28

  

  Acknowledgements This work was supported by grants from the Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R28), the National Basic Research Program of China (973) (Grant No.: 2013CB733602), the Major Research Plan of the National Natural Science Foundation of C

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