• The nAChR has been considered

  2024-05-15

  

  The α7 nAChR has been considered an interesting potential target for numerous therapeutic indications over the last two decades, with GTS-21 one of the first candidates proposed for Alzheimer's disease [2], [3], [23]. Unfortunately, although many α7-selective agonists have been developed [21], none

• The obtained results indicate that even when the

  2024-05-15

  

  The obtained results indicate that even when the impairment of the same forms of memory are present, amnesia can develop in different ways. Impairment of memory reconsolidation in the conditioned food aversion model through both the serotonin receptor antagonist and the antagonist of NMDA glutamate

• The role of DHT in

  2024-05-15

  

  The role of DHT in early teleost embryogenesis is not entirely clear or established, however additional studies that treat fish embryos to DHT or to specific srd5a inhibitors at critical stages of development (i.e. prior to sex differentiation) will shed light on the early functions of this androgen

• An AXL decoy receptor with

  2024-05-15

  

  An AXL decoy receptor with enhanced GAS6-binding properties, MYD1, was engineered as a therapeutic tool to disrupt GAS6/AXL signaling in vivo (Kariolis et al., 2014). MYD1 was shown to block metastasis of human ovarian cancer NVP 231 and a murine breast cancer cell line in grafting assays in mice.

• br Autophagy and cell death pathways in ischemic

  2024-05-15

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic Z-VDVAD-FMK synthesis injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great difference

• br Autophagy inducers Macroautophagy is often seen as a cell

  2024-05-15

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of Y-27632 and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective strategy for enhancing sensitivity of canc

• When skeletal muscle ages there is an increase in frailty

  2024-05-15

  

  When skeletal muscle ages, there is an increase in frailty, which is coincident with a decrease in muscle mass and function—this condition is called sarcopenia (Cruz-Jentoft et al., 2010). It has been shown that one of the major pathways downregulated at the onset of sarcopenia is the mitochondrial

• exemplifies three of the compounds investigated in

  2024-05-15

  

  exemplifies three of the compounds investigated in the selection for a candidate drug (CD). Our first criteria was an IC metabolic stability and poor pharmacokinetic properties. The triazole BLX-2477 () which had a decent IC in the cell assay (56nM) was more extensively investigated. Although it is

• Telomerase action at the telomere is highly regulated

  2024-05-15

  

  Telomerase action at the telomere is highly regulated; it preferentially elongates the shortest telomeres, and recruitment of the enzyme complex to the telomere occurs in mid-S phase of the cell cycle (Bianchi and Shore, 2007, Britt-Compton et al., 2009, Teixeira et al., 2004, Hemann et al., 2001, T

• The allosteric site of class C receptors is generally locate

  2024-05-15

  

  The allosteric site of class C receptors is generally located on the extracellular side of the TM domain (Brauner-Osborne et al., 2007, Christopher et al., 2015, Dore et al., 2014, Gregory et al., 2011, Harpsoe et al., 2017, Kniazeff et al., 2011, Pin and Prezeau, 2007, Urwyler, 2011, Wu et al., 201

• According to the diversity in molecular skeletons aromatase

  2024-05-15

  

  According to the mg132 in molecular skeletons, aromatase inhibitors can be categorized into two types: steroidal and non-steroidal blockers [6]. Steroidal AI (e.g., exemestane in Fig. 1) derived from the substrate androstenedione interacts with aromatase through chemical actions, resulting in an ir

• br Experimental Section br Results and Discussion br Conclus

  2024-05-15

  

  Experimental Section Results and Discussion Conclusions The advantages of the novel enzymo-chemical method for Mn and Co assay are simplicity of analytical procedure and economic effect due to the usage of only one enzyme in the form of apo-enzyme. An effectiveness of the apo-arginase-based

• Serum concentrations of acute phase proteins APP and

  2024-05-15

  

  Serum concentrations of acute phase proteins (APP) and of antioxidants have proved to be clinically useful biomarkers of pyometra in different species, including bitches, cows and mares [[11], [12], [13], [14], [15]]. Acute phase proteins are being increasingly used in both human and veterinary medi

• Several mechanisms of Cd induced carcinogenicity have been

  2024-05-15

  

  Several mechanisms of Cd-induced carcinogenicity have been reported and are comprehensively summarized by Hartwig [32]. As early as 1980, basic science studies supported a role for endocrine disruption of AR by Cd. Donovan et al. [33], using extracts of mouse prostate cytosol, showed Cd to be the mo

• Some of the mechanisms that involve LOX

  2024-05-15

  

  Some of the mechanisms that involve 12-LOX as a potential pathogenic enzyme are illustrated in Fig. 2. Direct β cell effects associated with the stimulation of 12-LOX activity include the activation of second messengers c-Jun N-terminal kinase and p38 MAPK, both of which show increased phosphorylati

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