• SJB2-043 The difficulty of characterizing nAChRs in the cent

  2024-12-13

  

  The difficulty of characterizing nAChRs in the central nervous system is also exemplified by early observations that nicotine caused no detectable effect when applied on a brain slice and it is only with the focal and high time resolution of more recent experiments that the effects of nicotinic neur

• br Patients and Methods br Results br Discussion Gjerdrum

  2024-12-13

  

  Patients and Methods Results Discussion Gjerdrum et al showed that Axl 78 2 is required to maintain the mesenchymal-like invasiveness of metastatic breast carcinoma cells, but Axl knockdown has no effect on the cell proliferation of MDA-MB-231 cells. Mackiewicz et al also showed that down-

• Our results suggest that plasma

  2024-12-13

  

  Our results suggest that plasma membrane and a3-containing V-ATPases represent an important and novel target in the development of drugs to limit breast cancer metastasis. That knock-down of a3 has been shown to reduce metastasis of melanoma cells in an in vivo mouse model suggests that this role ma

• exemplifies three of the compounds investigated in

  2024-12-13

  

  exemplifies three of the compounds investigated in the selection for a candidate drug (CD). Our first criteria was an IC SNS-314 Mesylate synthesis as such did not show any genotoxicity in the SOS/umu assay, but this does not say anything about any possible genotoxicity of its metabolites or degrada

• br Mechanisms of GPCR internalization Like for other types

  2024-12-13

  

  Mechanisms of GPCR internalization Like for other types of receptors, prolonged agonist stimulation often leads to GPCR internalization, which can occur via different pathways ∗[2], [20], [21], [22], [23]. Of these pathways, clathrin-mediated csf-1r (CME) is the best characterized and arguably m

• Human hepatocyte transplantation resulted in some animals wi

  2024-12-13

  

  Human hepatocyte transplantation resulted in some animals with relatively sparse repopulation while others had >90% of their liver containing human hepatocytes. The presence of circulating human albumin varied based on the amount of repopulation as the degree of humanization is reported to correlate

• br Materials and methods br Results br Discussion Japanese e

  2024-12-13

  

  Materials and methods Results Discussion Japanese encephalitis caused by JEV is characterized by Ciprofibrate neuron death. However, the underlying mechanism is not fully understood. We and other researchers have demonstrated that JEV induces apoptosis by ER stress-mediated IRE1/JNK and RO

• Apelin is a bioactive peptide and

  2024-12-13

  

  Apelin is a bioactive peptide and endogenous ligand for the APJ receptor (APLNR), a member of the G protein coupled receptor family that shares a similar sequence as the angiotensin type-1 receptor (AT1) [5]. Early studies demonstrated that the apelin/APLNR receptor axis plays a significant role in

• br Future view and implications The selection and

  2024-12-13

  

  Future view and implications The selection and spread of multi(drug)-resistant microorganisms over the last decades has become a major and global public health concern [35]. Two growing threats originating from the fungal kingdom, i.e. Aspergillus fumigatus and Candida auris[36], [37], re-emphasi

• For the time being fluorescent in situ hybridization

  2024-12-12

  

  For the time being, fluorescent in situ hybridization (FISH) remains the ‘gold standard’ for ALK rearrangements diagnosis but immunohistochemistry has become a widely used pre-screening tool and the FDA recently approved the Ventana ALK (D5F3) CDx Assay (Ventana Medical Systems, Tucson, AZ) as a com

• ALK fusion positive NSCLC is clinically actionable because

  2024-12-12

  

  ALK fusion-positive NSCLC is clinically actionable because it can be targeted by several FDA-approved drugs, including the first generation TKI crizotinib, which is a dual inhibitor to MET and ALK [15], and the second generation inhibitors, alectinib and ceritinib, both of which are highly-selective

• br Conflict of interest br

  2024-12-12

  

  Conflict of interest Introduction The Piezo proteins, Piezo1/FAM38A and Piezo2/FAM38B, are multi-pass transmembrane proteins that have been identified as mechanically-activated (MA) homomultimeric, pore-forming ion channels [1,2]. Piezo1 is broadly expressed with its highest expression in blad

• In addition to plasma membrane sites OCT was

  2024-12-12

  

  In addition to plasma membrane sites, OCT3 was also observed associated with endomembranes, including mitochondrial membranes, with particularly strong expression in the outer nuclear membranes of both neurons and astrocytes (Gasser et al., 2017), indicating that, in addition to regulating extracell

• Constitutive tyrosine kinase activity of BCR ABL fusion gene

  2024-12-12

  

  Constitutive tyrosine kinase activity of BCR/ABL fusion genes causes uncontrolled cell growth and is also thought to be responsible for a variety of changes in normal cellular functions like differentiation, adhesion, migration and apoptotic response in CML. Therefore it is important to know the exp

• br Conclusions and clinical relevance Astrogliosis and an

  2024-12-12

  

  Conclusions and clinical relevance Astrogliosis and an increase in ADK is a pathologcial hallmark of epilepsy. The consequence of increased ADK in the epileptic CH5138303 australia is a decrease in the ambient adenosine tone and A1R activity. As a result, systemic administration of A1R agonists o

15843 records 41/1057 page Previous Next First page 上5页 4142434445 下5页 Last page