• br Conflict of interest br Acknowledgements

  2021-02-25

  

  Conflict of interest Acknowledgements This work was supported by the Basic Science Research Program through the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (2013R1A1A1076117) and also by the Priority Research Centers Program through the NRF funde

• Due to the high attractiveness of E and E ligases

  2021-02-25

  

  Due to the high attractiveness of E2 and E3 ligases as drug targets, a number of drug discovery assays have been published, based on detection by fluorescence (Dudgeon et al., 2010, Krist et al., 2016, Zhang et al., 2004), GDC-0834 (Davydov et al., 2004, Huang et al., 2005, Kenten et al., 2005, Marb

• br Conflict of interest br Acknowledgements The authors are

  2021-02-25

  

  Conflict of interest Acknowledgements The authors are grateful to laboratory technician Kristina Andersson for expert technical assistance. The authors acknowledge the Swedish Research Council (Grant no. 6834), Region Skåne and Faculty of Medicine, Lund University, for financial support. In

• br DAG kinase activity is confined to specific cell

  2021-02-25

  

  DAG kinase activity is confined to specific cell compartments A number of reports demonstrating agonist-dependent translocation of DGKs to distinct membrane compartments suggest that DGK activity is restricted to localized DAG pools generated after activation of receptors. Perhaps the best eviden

• In anticipation of an approach based on

  2021-02-24

  

  In anticipation of an approach based on modification of the cyclohexylacetic flumethasone subunit of 1 as a means of improving permeability, a set of analogs were prepared to map out the optimum display of the acidic functionality. Homologated acids 25 and 26 were found to be equipotent to 1, altho

• DDR plays a crucial role in regulating a

  2021-02-24

  

  DDR2 plays a crucial role in regulating a wide variety of fundamental cellular processes, including cell proliferation, differentiation, and adhesion [17], [28], [29], [30]. The authors revealed compromised cell migration in DDR2-silenced fibroblasts exposed to Ang II, most likely due to the loss of

• To overcome problems with the biochemical reconstitution of

  2021-02-24

  

  To overcome problems with the biochemical reconstitution of these heterodimeric cytokines fusion strategies linking both subunits together have been proposed inspired by the “hyper-IL-6” [28]. Much like fusing a protein to a solubility enhancing protein such as MBP or SUMO, fusing two subunits of a

• Sterol regulatory element binding proteins SREBPs regulate

  2021-02-24

  

  Sterol regulatory element binding proteins (SREBPs) regulate transcription of genes involved in fatty latanoprost synthesis [38] (fatty acid synthase, and acetyl-CoA carboxylase) as well as triglyceride synthesis [39]. SREBP-1 protein levels are reduced in 3T3-F442A adipocytes [40] and increased in

• br Materials and methods br Results and discussion Iron II

  2021-02-24

  

  Materials and methods Results and discussion Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases [28], [29] catalyze oxidative reactions of a range of metabolic processes including the hydroxylation of l-proline and l-lysine residues during the post-translational modification of collagen. Mor

• Three new trans P Hs AlP H MiP H

  2021-02-24

  

  Three new trans-P4Hs (AlP4H, MiP4H and ScP4H) discovered by a genome mining approach in this study were all located in branch A containing DaP4H sequence. Although another three candidates from Amycolatopsis mediterranei, Bradyrhizobium sp. ORS285 and O. indicum were successfully expressed as solubl

• What is the predominant mechanism underlying the benefits of

  2021-02-24

  

  What is the predominant mechanism underlying the benefits of udenafil, i.e. the vascular vs. myocardial effect? Lewis et al. suggested that the benefit of sildenafil in HFrEF would be derived from augmented RV systolic function that mainly results from pulmonary vasodilation, suggestive of the ‘vasc

• Glycolysis is important to maintain the vital functions of T

  2021-02-24

  

  Glycolysis is important to maintain the vital functions of T. gondi. Extracellular T. gondii shift its lipid metabolism metabolism towards glycolysis, based on the observation that a relocation of glycolytic enzymes from the cytosol to the pellicle occurs at the time when tachyzoites egress from hos

• br In some but not all

  2021-02-24

  

  In some, but not all, human vessels, a small population of ETB (usually interleukin 2 receptor with atherosclerotic lesions did not show any increase. In agreement, in experimental medicine studies in both heart failure patients and volunteer controls, selective ETA antagonism (BQ123) caused the e

• ampa receptor br Materials and methods Details

  2021-02-24

  

  Materials and methods Details on materials and methods can be found in the Supplemental material section. Results Discussion In our experiments we mimicked inflammation by LPS challenge of M0 macrophages. We discovered a strong increase in expression of CH25H and CYP7B1 while CYP27A1 and H

• Other GPCRs notable for changes in expression on CLL cells

  2021-02-24

  

  Other GPCRs notable for changes in expression on CLL cells include upregulation of the thromboxane A2 receptor TBXA2R mRNA [61] and up and downregulation of mRNA and protein from the neurotensin receptors NTSR2 and NTSR1, respectively [62]. The Eμ-TCL1 mouse model of CLL has been used to study mult

15823 records 675/1055 page Previous Next First page 上5页 671672673674675 下5页 Last page