• Despite advances in our understanding of

  2020-07-31

  

  Despite advances in our understanding of the overall topology of the RING-E2~Ub complex (Dou et al., 2012, Dou et al., 2013, Plechanovova et al., 2012), and the importance of reducing conformational freedom for catalysis (Berndsen et al., 2013), a detailed mechanistic understanding of ubiquitin tran

• br Methods br Results br Discussion Reduced memory capacity

  2020-07-31

  

  Methods Results Discussion Reduced memory capacity is a core cognitive symptom of schizophrenia [2,[4], [5], [6], [7], [8],[11], [12], [13], [14], [15], [16], [17], [18], [19]] and an early marker of ageing-associated cognitive decline [17]. In this study, using a pharmacological approach,

• Numerous studies focused on the mechanisms

  2020-07-31

  

  Numerous studies focused on the mechanisms underlying allosteric changes induced receptor heteromerization and associated modification of downstream signaling but only few reports described roles of endogenous heteromers in vivo (Table 1). This is likely due to limitations of current approaches to d

• The imaging and biochemical data presented here demonstrated

  2020-07-30

  

  The imaging and biochemical data presented here demonstrated that in T cells, AEP played a specific function in cleaving Foxp3 but not Tbet. These results are in accordance with previous AEP studies where it has been shown that AEP substrates in part are not amenable to other protease activity. In a

• FOX proteins constitute a large class of transcription facto

  2020-07-30

  

  FOX proteins constitute a large class of transcription factors with multiple functions, from development and organogenesis to regulation of metabolic and immune functions. The Fox transcription factor is characterized by a 100-amino-acid wing helix or forkhead DNA-binding domain. In addition, the FO

• Based on published reports and our own findings we propose

  2020-07-30

  

  Based on published reports and our own findings, we propose to combine genetic inactivation with pharmacological inhibition in mechanistic studies because the selectivity of many commercially available inhibitors is often limited. Experiments with non-selective inhibitors easily lead to misleading c

• In this study Oncomine GEO

  2020-07-29

  

  In this study, Oncomine, GEO and TCGA databases were used to analyze the expression of UBE2S gene in HCC and normal liver tissues to determine the relationship between UBE2S expression and prognosis of hepatocellular carcinoma. The potential function of UBE2S in HCC was analyzed by screening UBE2S c

• RecBCD is a combination helicase nuclease

  2020-07-29

  

  RecBCD is a combination helicase/nuclease that is critical to homologous genetic recombination and DNA repair in E. coli., The holoenzyme consists of the three subunits RecB, RecC, and RecD. The RecB and RecD subunits are NTP hydrolysis-dependent DNA motor proteins that drive DNA translocation and s

• In addition to myogenic differentiation previous studies sug

  2020-07-29

  

  In addition to myogenic differentiation, previous studies suggested that DGKδ, which is also expressed in adipose tissue, is involved in not only adipocyte differentiation [30] but also its lipogenesis [46]. We reported that DGKδ regulates the formation of long axons/neurites (differentiation) in pr

• Here we use RNA sequencing RNA seq chromatin

  2020-07-29

  

  Here, we use RNA sequencing (RNA-seq), chromatin immunoprecipitation sequencing (ChIP-seq) and rapid amplification of cDNA ends (RACE) to map the human SYNE1 transcriptome, providing a framework for localizing the multiple disease-associated mutations identified in this complex gene in relation to s

• Current evidence about cell selective actions of

  2020-07-28

  

  Current evidence about cell-selective actions of striatal D2Rs stems primarily from D2R deletion throughout striatum or from local D2R overexpression, but the use of cell- and region-specific knockdown approaches in the adult YM 022 synthesis has been limited and should be considered. Moreover, met

• myc inhibitor Introduction Double strand break DSB is the mo

  2020-07-28

  

  Introduction Double strand break (DSB) is the most deleterious damage that threats DNA integrity. This frequent damage arises from environmental stress like UV, chemical agents or ionizing radiations (IRs). Although environmental stress does not lead directly to DSB, it produces myc inhibitor damag

• Introduction Human cytomegalovirus CMV is

  2020-07-28

  

  Introduction Human cytomegalovirus (CMV) is a herpesvirus which has a ubiquitous and worldwide distribution, and is the most frequent cause of congenital infection (Kenneson and Cannon, 2007). The prevalence is around 0.5–1% of all live births and is the leading cause of sensorineural hearing loss

• br CK signaling during ischemia in brain

  2020-07-28

  

  CK2 signaling during ischemia in brain GM In GM, CK2 signaling can be either protective or damaging. For example, in a model of transient forebrain ischemia, the preservation or activation of CK2 activity was proposed to be important for neuronal survival after cerebral ischemia [8]. Specifically

• br Experimental procedures br Introduction Protein kinases r

  2020-07-27

  

  Experimental procedures Introduction Protein kinases represent one of the largest enzyme liver x receptor in the human genome and act as signaling mediators in a variety of cellular processes (Manning et al., 2002). Because many diseases are associated with aberrant protein kinase activity, ta

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