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Autophagy can be generally divided into
2019-06-13
Autophagy can be generally divided into non-selective bulk autophagy and selective autophagy. Non-selective autophagy breaks down proteins and organelles to provide the cell with nutrients in response to starvation. Selective autophagy removes damaged and excess organelles as well as protein estroge
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Sadly cytomegalovirus retinitis remains the neglected diseas
2019-06-13
Sadly, cytomegalovirus retinitis remains the neglected disease of the AIDS pandemic, and there is an increasing group of young patients in low-income and middle-income countries made healthy by successful treatment of underlying HIV, yet left permanently blind from undiagnosed or inadequately treate
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De hecho la desordenada colecci
2019-06-13
De hecho, la desordenada colección de los datos etnográficos se encuentra varias veces en conflicto con la propuesta de un proyecto sistemático que el fraile busca plantear, sin éxito, en el exordio de su obra. En las primeras páginas de la Relación, Pané esboza los confines de un modelo hermenéutic
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Ya en el siglo xx la Historia verdadera y las
2019-06-13
Ya en el siglo xx, la Historia verdadera (y las crónicas de Indias en general) ha sido recuperada como origen de la literatura latinoamericana contemporánea, en especial por escritores vinculados tnf alpha inhibitor la literatura del boom: Alejo Carpentier, Gabriel García Márquez, Carlos Fuentes. De
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Di logo de amigos escritura
2019-06-13
Diálogo de amigos, escritura y ficción se cruzan desde las primeras páginas: “Por dispares que fuéramos como escritores, la amistad cabía, porque sentíamos una compartida pasión por los libros. Tardes y noches conversamos de Johnson, de De Quincey, de Stevenson, de literatura fantástica, de argument
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According to Weitzman classification patients had a single O
2019-06-12
According to Weitzman classification [43] 15 patients had a single ONJ lesion (4A) and 9 patients had multiple lesions (4B) or a “multifocal” lesion (Table 2). Six patients interrupted the treatment with O3 gas application for disease progression (five patients) and for fear of an experimental ther
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Evidence of a variant induction of apoptosis to
2019-06-12
Evidence of a variant induction of apoptosis to vorinostat in different DLBCL cell lines according to HAT mutational status implies that defects in CREBBP/EP300 could potentially explain the heterogeneous observations in clinical trials of vorinostat in NHL. These findings, however, need to be confi
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An anteroposterior AP radiograph of
2019-06-12
An anteroposterior (AP) radiograph of the pelvis and lateral radiograph of the right hip demonstrated moderate degenerative changes of both hips (Figs. 1 and 2). A provisional differential diagnosis of early avascular necrosis (AVN) or femoroacetabular impingement (FAI) was made. Renal function and
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The findings of Peck and colleagues are
2019-06-12
The findings of Peck and colleagues are in major ways expected and apply to many developing countries. However, the quest for solutions must integrate many other important questions. To what extent is the report by Peck and colleagues specific for NCDs and not only a reflection of an overall non-opt
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Importa recordar que el intelectual acad mico siempre se
2019-06-12
Importa recordar que el intelectual académico siempre se ha sentido incómodo en su propia piel. Leer y escribir rigurosamente pueden ser actos radicales en sí, pero la relación del intelectual y la academia suele exigir sospecha, mucho más que la del artista y el mercado, o la del político y el part
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Polymorphic VT VF storms can occur
2019-06-11
Polymorphic VT/VF storms can occur in patients with severe Cilengitide failure, independent of their underlying causes. Recent experimental studies using a pacing-induced heart failure model showed that heart failure facilitates acute shortening of the APD immediately after VF termination [73]. Per
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MIP binds to three different receptors CCR
2019-06-11
MIP-1α binds to three different receptors: CCR1, CCR5 and CCR9. CCR1 and CCR5 are expressed on MM calcifediol and stromal cells. Inhibitors to CCR1 and CCR5 have been used to delineate the roles of each receptor in the myeloma bone marrow microenvironment[69]. Menu and colleagues demonstrated that
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MiR a rs is situated in
2019-06-11
MiR-196a2 rs11614913 is situated in the 3′ passenger strand mature sequence of miR-196a2. The C to T mutation of the rs11614913 SNP, which was located in the stem region of an miR-196a-2 precursor, leads to a change from a G:C to a G:U mismatch. A previous study has shown that miR-196a2 rs11614913 c
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According to several cases earlier reported by Gandhi
2019-06-11
According to several cases earlier reported by Gandhi et al, the median time of acute pancreatitis occurring is 12 days (range: 9–16 days), from the last administration of BV, and most events occurred in the first course of BV treatment. One patient experienced recurrent pancreatitis in the fifth co
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In addition to inducing IKs dysfunction through dominant
2019-06-11
In addition to inducing IKs dysfunction through dominant-negative loss-of-function effects and defective channel trafficking, mutations in KCNQ1 suppress IKs channel function by reducing the channel affinity of interacting proteins [68,69]. Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor
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