• br Results br Discussion As previously reported

  2018-11-08

  

  Results Discussion As previously reported, human based hNSC fate analysis was found to be a very subjective and inconsistent method even when human observers are experienced. The greatest variation in human based manual cell quantification both between individuals and between repeated analyses

• Many protocols include the inhibition

  2018-11-08

  

  Many protocols include the inhibition of BMP, Nodal and Wnt signaling pathways to achieve neural induction (Fig. 2) (for review see Gaspard and Vanderhaeghen, 2010). To this end, signaling inhibitors such as Noggin, Lefty (Lefty1, Lefty2, or LeftyA) and Dickkopf-1 (Dkk-1) have all been used to promo

• Interestingly we found that IG DMR was

  2018-11-08

  

  Interestingly, we found that IG-DMR was hypermethylated in the MEFs and mouse tail cells in comparison to ES cells (Figs. 2A and 3SA). This may be a result of IG-DMR imprinting in a tissue-specific manner. Indeed, it had been reported before that IG-DMR is hypermethylated in postnatal neural stem ce

• Potential candidates contributing to the fate

  2018-11-08

  

  Potential candidates contributing to the fate determination in the injured spinal cord include bone morphogenetic proteins (BMPs) — in particular BMP2 and BMP4, which strongly promote astroglial differentiation at the expense of oligodendroglial and neuronal differentiation (Bonaguidi et al., 2005;

• Interestingly our data showed that when eLSKSLAM were co cul

  2018-11-08

  

  Interestingly, our data showed that when eLSKSLAM were co-cultured with individual ploidy MM, the significant increase in proliferation was no longer observed. In addition, we observed less than expected proliferation when eLSKSLAM I-BET-762 were co-cultured with MM that had been stained with Hoechs

• OCT NANOG and THY are referred

  2018-11-08

  

  OCT4, NANOG, and THY1 are referred to as stem cell pluripotency markers. NANOG is expressed in porcine male germ cells, but OCT4 is not expressed in gonocytes of neonatal testes (Goel et al., 2008). However, OCT4 expression is detected in 2week cultures of PGP9.5 positive porcine spermatogonia from

• A paradoxical outcome of dietary SPI

  2018-11-08

  

  A paradoxical outcome of dietary SPI exposure is the shorter latency of Wnt1-generated mammary tumors, despite the significant reduction in tumor incidence in SPI-fed mice. We previously reported that in female rats exposed to SPI and administered with the direct acting carcinogen N-methyl-nitrosour

• br Acknowledgments We thank Mrs Jessica Franzot

  2018-11-08

  

  Acknowledgments We thank Mrs Jessica Franzot for technical support with Western blotting. This work was supported by grants from the government of the Friuli Venezia Giulia Region (SPINAL project), the Fund for Transregional Cooperation (MINA project), and the IBRO Return Home Programme Grant (to

• The following are the supplementary data

  2018-11-08

  

  The following are the supplementary data related to this article. Contribution statement O.K., J.J.K. and Y.K. participated in designing the experiments, execution of described works, statistical analysis, interpretation of data and writing the manuscript. H.-S.K., M.H., O.E., C.L., C.V. and T.

• The following are the supplementary data related to this

  2018-11-08

  

  The following are the supplementary data related to this article. Acknowledgments Introduction Vascularization is essential in tissue engineering approaches. This is evident by the limited diffusion distance of oxygen from blood vessels into surrounding tissue, which ranges between 150 and 20

• ALS is a fatal neurodegenerative disorder

  2018-11-08

  

  ALS is a fatal neurodegenerative disorder characterized by a selective and widespread degeneration of lower and upper motor neurons (Gordon, 2013; Rowland and Shneider, 2001). The main symptomatic features of ALS are muscular atrophy, motor paralysis and difficulties in speaking, swallowing, chewing

• br Author contributions br Grant

  2018-11-08

  

  Author contributions Grant support The study received the Bardhan Research and Education Trust (BRET) (14345) support. Disclosures Acknowledgements Many thanks to the Bardhan Research and Education Trust (BRET) (14345) , which supports research into digestive diseases, for funding the w

• br Results br Discussion The

  2018-11-08

  

  Results Discussion The availability of Lgr5 as a specific marker for stem A-1210477 in the intestine and other tissues has allowed the unequivocal identification of intestinal stem cells, as well as molecular profiling (Muñoz et al., 2012), the establishment of culture methods (Sato et al., 2

• Chemotherapy is a standard treatment for patients

  2018-11-08

  

  Chemotherapy is a standard treatment for patients with advanced disease, including nonresectable, recurrent, or metastatic tumors. Due to chemoresistance, the majority of patients die within three years (Papaspyrou et al., 2011). Indeed, cisplatin and other platinum-based therapies do not present cl

• Since the discovery of these cells Ingram et al

  2018-11-08

  

  Since the discovery of these Leupeptin (Ingram et al., 2004), secondary colonies have been generated in several studies to assess the immaturity of ECFCs from blood or vascular wall and hierarchize them (Alphonse et al., 2015; Ingram et al., 2005; Patel et al., 2016). The aim of this work was to ide

15072 records 988/1005 page Previous Next First page 上5页 986987988989990 下5页 Last page