• Stanford claims that three cardinal sins should

  2018-10-29

  

  Stanford claims that three cardinal sins should be avoided at all costs: subordinating history to any non-historical theory or ideology, such as religious, economic, philosophical, sociological, and political; neglecting breadth (i.e., failing to take all considerations into account and to do justic

• Preoperative imaging modalities such as contrast enhanced ab

  2018-10-29

  

  Preoperative imaging modalities, such as contrast-enhanced abdominal CT, facilitate diagnosis. Helical CT plays a crucial role in the diagnosis of intraluminal or exophytic tumors. The differential diagnosis of GI tract tumors should include fibromatosis, leiomyoma, schwannoma, inflammatory fibroid

• br Results Fish borne nematode parasites of zoonotic importa

  2018-10-29

  

  Results Fish-borne nematode parasites of zoonotic importance and respective fish hosts in Brazil are indicated in Table 1. Anisakis spp. were reported from 44 different host species, Pseudoterranova spp. from 16 hosts, Hysterothylacium spp. from 57 hosts, Eustrongylides spp. from 46 hosts, Contra

• br Mechanism of action of probiotics The actual mechanism of

  2018-10-29

  

  Mechanism of action of probiotics The actual mechanism of action of probiotics has not been clearly understood, however, documented results are those obtained from animal models and in vitro experiments. One mode of action of probiotics may be an improvement of the barrier functions of the gut mu

• The XCI status of different

  2018-10-29

  

  The XCI status of different hESCs was previously analyzed mainly by XIST papain inhibitor and was not conclusive (Hoffman et al., 2005; Adewumi et al., 2007; Shen et al., 2008; Silva et al., 2008; Dvash and Fan, 2009; Dvash et al., 2010). We now propose to characterize the status of X inactivation

• br Experimental Procedures br Author Contributions

  2018-10-29

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Pluripotent stem RGDfK (PSCs) have the remarkable capacity to generate all cell types of the body (Thomson et al., 1998). Potential biomedical applications for the derivatives of PSCs are vast and diverse, includin

• Smooth muscle cells are characterised by the specific expres

  2018-10-26

  

  Smooth muscle cells are characterised by the specific expression of several proteins such as α-smooth muscle Silmitasertib (α-SMA), transgelin (SM22α), calponin and smooth muscle myosin heavy chain (MYH11) (Owens, 1995). α-SMA, encoded by the Acta2 gene, is one of the six actin genes expressed in ma

• Interferons are a diverse family of cytokines which possess

  2018-10-26

  

  Interferons are a diverse family of cytokines which possess antiviral and immunomodulatory properties (Isaacs and Lindenmann, 1957; Stark et al., 1998; Theofilopoulos et al., 2005). These specialized proteins are produced by cells in response to viral infection. Cellular sensors such as retinoic tro

• toward It is often pointed out that

  2018-10-26

  

  It is often pointed out that tumor toward can escape immune cells by changing their antigenicity through the modification of targeted peptide sequences or reduction of HLA-molecule expression (Schreiber et al., 2011). This is usually the case when immune therapies with antigen-specific monoclonal CT

• find more The adult mammalian kidney is an organ with very l

  2018-10-26

  

  The adult mammalian kidney is an organ with very low cell cycling during homeostasis but remarkable proliferating capacity after injury. It is still unresolved whether the kidney contains bona fide stem cells. Humphreys et al. (2008) genetically marked cells using Six2, a transcription factor expres

• br Experimental Procedures br Author Contributions All

  2018-10-26

  

  Experimental Procedures Author Contributions All authors fulfill the ICMJE guidelines for authorship. E.B.B., Y.L.T., Y.P.P., S.L., H.S.C., Q.D., and S.-B.J. performed the biological experiments. Y.L.T. and D.R. performed the bioinformatics part of the study. A.L., X.L., C.S., S.-B.J., and U.L

• br Introduction Cardiac morphogenesis results from

  2018-10-26

  

  Introduction Cardiac morphogenesis results from the specification, differentiation, and migration of spatially and temporally distinct sets of cardiac precursor beta lactamase that give rise to the mature cardiac tissue. The first multipotent cardiogenic cells originate from the mesoderm formed

• sirtuin We show that the GCase defect was

  2018-10-26

  

  We show that the GCase defect was associated with impaired autophagosome formation in the N370S GBA1 mutation dopaminergic haNCSCs, in agreement with Schondorf et al. (2014). We have shown that ambroxol rescues the biochemical abnormalities resulting from the N370S mutation. Ambroxol increased GCase

• Although due to limitations of

  2018-10-26

  

  Although, due to limitations of the current tools and technical challenges, we could not perform direct manipulation of the 11 miRNAs to rescue/inhibit neurogenesis in vivo, we demonstrated that most of these miRNAs are expressed in adult-born hippocampal neurons, and consequently depleted upon the

• Using the measured approach curves we determined the force a

  2018-10-26

  

  Using the measured approach curves, we determined the force acting on the probe from the sample surface as the product of the cantilever spring constant k by the piezoscanner movement value dZ (this quantity is plotted on the abscissa in Fig. 2b). Next, we constructed the F(δ) dependences to find Yo

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