• ABT-737: Dissecting Mitochondrial Apoptosis via BCL-2 Inh...

  2025-09-19

  Explore the mechanistic role of ABT-737, a leading BH3 mimetic and BCL-2 protein inhibitor, in unraveling the mitochondrial apoptosis pathway and its implications for cancer research. This article provides a rigorous analysis of ABT-737’s selectivity, its intersection with recent findings on nuclear-mitochondrial apoptotic signaling, and practical insights for experimental design.

• Plerixafor (AMD3100): Mechanistic Insights for CXCR4 Axis...

  2025-09-18

  Explore the multifaceted role of Plerixafor (AMD3100), a CXCR4 chemokine receptor antagonist, in cancer metastasis inhibition, hematopoietic stem cell mobilization, and neutrophil trafficking. This article provides a mechanistic and comparative analysis of its research applications, emphasizing advances in CXCR4 signaling pathway modulation.

• So far many independent studies have linked

  2025-03-03

  

  So far, many independent studies have linked cholesterol metabolism–related genes with AD, either by showing associations with specific polymorphisms or with differential BCA Protein Quantitation Kit levels (Beecham et al., 2014, Blain and Poirier, 2004, Lambert et al., 2009, Lambert et al., 2013,

• br Conflict of interest br Acknowledgement

  2025-03-03

  

  Conflict of interest Acknowledgement This study was supported by a grant from University Grants Commission - Basic Scientific Research (UGC-BSR), New Delhi, India (UGC-BSR No:F-7-115/2007). Introduction The G protein-coupled receptors activated by extracellular adenosine (Ado), called Aden

• LR3 IGF-1 Peptide In this study PRP positively regulated MII

  2025-03-03

  

  In this study, PRP4 positively regulated MIIP levels and significantly inhibited the invasion of HCT116 cells. Further investigations elucidated that PRP4 dephosphorylated MIIP via PP1A regulation, which was confirmed by PP1A inhibition in the presence of OA. Upon dephosphorylation, MIIP possibly in

• Nutritional supplement br Discussion The clinical course of

  2025-03-03

  

  Discussion The clinical course of our patient until May 2012 was rather typical of early onset AChR-MG. Later on, the pattern of the disease was more typical of MuSK-MG, as evidenced by the distribution of myasthenic weakness and the unprovoked exacerbations. The Nutritional supplement of MuSK-M

• In an effort to determine

  2025-03-03

  

  In an effort to determine if one 5ARI was more effective than the other, the Enlarged Prostate International Comparator Study (EPICS) [17] compared treatment with finasteride and dutasteride in 1630 men over the age of 50 and concluded that after one year of treatment, both groups had statistically

• Zhang et al screened three thousand compounds

  2025-03-03

  

  Zhang et al. screened three thousand compounds library and found two active 3,5,6-substituted indolin-2-one molecules. Further, they designed various derivatives of this scaffold and among them compound 23 from the series was found active with 1.8 μM on Aurora-B kinase luminescent assay [53]. Jeffe

• IGF signaling has been shown to induce chromatin changes

  2025-03-01

  

  IGF-1 signaling has been shown to induce rna polymerase ii changes via interacting with MKK-p38 signaling (Serra et al., 2007) and by perturbing Foxo3a signaling (Stitt et al., 2004), among other mechanisms. The current study demonstrates that the acetyl group itself may be limiting, since IGF-1/ACL

• In conclusion the partial sequencing and characterization

  2025-03-01

  

  In conclusion, the partial sequencing and characterization of R. quelen cyp19a1b provides essential information about this gene and its presence in peripheral tissues outside of the central nervous system in a teleost. Furthermore, we covered sex differences in the effects of E2 on the cyp19a1b gene

• br Introduction Hepatocellular carcinoma HCC is an

  2025-03-01

  

  Introduction Hepatocellular carcinoma (HCC) is an aggressive and malignant cancer detected in clinical practice, as it is the third key reason of tumor-related deaths worldwide, with > 800, 000 mortalities every year (Torre et al., 2015). Current treatments for HCC are surgical therapy, liver tra

• Reactive oxygen species is an

  2025-03-01

  

  Reactive oxygen species is an aspect of oxidative stress which are associated with many diseases such as rheumatoid arthritis, diabetes, inflammation, atherosclerosis and cancers (Collins, 2005; Halliwell, 1994). Thus, the need for naturally occurring antioxidants is of crucial importance. Some biop

• Inhibition of autophagy has been

  2025-03-01

  

  Inhibition of autophagy has been shown to alleviate neuronal damage after cerebral ischemia, both in cell culture and rodent models (Koike et al., 2008, Li et al., 2015, Wang et al., 2016, Zhang et al., 2014, Zheng et al., 2014). Therefore, blockage of autophagy is a potential target for prevention

• br Neurological development and BCAAs Glutamate is an import

  2025-03-01

  

  Neurological development and BCAAs Glutamate is an important excitatory neurotransmitter in the brain, and BCAAs (especially leucine) function to synthesize glutamate in astrocytes around neurons, since leucine enters the brain from the blood more rapidly than other BGJ398 and provides ∼25% of a

• The overall adjustment the non toxicity and the

  2025-03-01

  

  The overall adjustment, the non-toxicity and the addiction-free treatment methods are the advantages of EA. EA treatment for depression has achieved great clinical effect in recent years (Dong et al., 2017). The clinical practice guideline of the American college of physicians (ACP) have pointed out

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