• br Introduction Stem cell divisions resulting

  2018-11-06

  

  Introduction Stem cell divisions resulting in alternative pathways of self-renewal or differentiation require very distinctive epigenetic regulation of gene expression from the same genome. Where division has a symmetrical output of progeny cells, the assumption is that the molecular signatures d

• br Introduction Transplantation of hepatocytes

  2018-11-06

  

  Introduction Transplantation of hepatocytes (HTx) has been shown to be useful for patients with chronic or acute liver failure or genetic defects in liver function (Strom et al., 1997; Fisher et al., 2000; Fisher and Strom, 2006; Strom et al., 2006; Fox et al., 1998; Horslen et al., 2003; Muraca

• tsa trichostatin We hypothesized that type B astrocytes migh

  2018-11-06

  

  We hypothesized that type B astrocytes might be among the other SVZ-derived cell types able to migrate in response to a damage insult. In this study we used Nilo1, a previously characterized mAb that identifies early neural progenitors in the SVZ niche (Del Valle et al., 2010), demonstrating that Ni

• To ultimately test the functional pacemaker activity of the

  2018-11-06

  

  To ultimately test the functional GSK343 activity of the iSABs, we took advantage of the ex vivo model based on cultivated ventricular slices of murine hearts (Halbach et al., 2006; Figure 6A). Although such slices typically have spontaneous beating activity immediately after preparation, they can

• Although due to limitations of

  2018-11-05

  

  Although, due to limitations of the current tools and technical challenges, we could not perform direct manipulation of the 11 miRNAs to rescue/inhibit neurogenesis in vivo, we demonstrated that most of these miRNAs are expressed in adult-born hippocampal neurons, and consequently depleted upon the

• The molecular mechanisms underlying calreticulin s effects

  2018-11-05

  

  The molecular mechanisms underlying calreticulin\'s effects on cardiac development continue to be elucidated. It is known that intranuclear translocation of cardiogenic transcription factors is affected by calcineurin, a Ca2+∕calmodulin-regulated cytosolic phosphatase (Crabtree, 1999; Frey et al., 2

• The value of can be significantly lower than

  2018-11-05

  

  The value of can be significantly lower than the initial elastic modulus of the material containing no hydrogen, as The above equation clearly illustrates the strong effect that the concentration of the attached hydrogen particles has on the total elastic modulus: the higher the proportion of the

• Expansion is a canonical white noise expansion in terms

  2018-11-05

  

  Expansion is a canonical white-noise expansion in terms of a wavelet basis, i.e., it is a sum of random quantities multiplied by determinate time-varying functions, in this case, wavelet ones. Amiantov\'s study proved, in particular, the assumption that the probability density functional takes the

• In agreement with the results of

  2018-11-05

  

  In agreement with the results of the previous studies conducted in our laboratory, it was found that the regulation of the STIM2→nSOCE signaling pathway was impaired in 5×FAD mice. It was established that downregulated STIM2 expression was observed as early as at the age of 4 months. At this age, do

• A marginal structural model by means of additive

  2018-11-05

  

  A marginal structural model by means of additive hazard regression was thereafter applied to mortality. Additive hazard regression is a flexible model for survival analyses with the linear dependence of the model facilitating decomposition into direct, indirect, and total effects (Lange & Hansen, 20

• Previous studies conducted in Japan targeted only

  2018-11-05

  

  Previous studies conducted in Japan targeted only mothers who cared for children with disabilities and lacked reference subjects, such as mothers of children without disabilities (Toki et al., 2010; Yamaguchi, Takataya & Ogiwara, 2005; Yamaoka et al., 2015; Yatsugi, Suzukamo & Izumi, 2013). Furtherm

• Only a handful of studies

  2018-11-05

  

  Only a handful of studies examined the RD-health association outside the U.S. and Europe; all revealed strong evidence that, above and beyond absolute income, RD is an important predictor. In research using a large probability sample of Japanese men and women, RD measured by the Yitzhaki Index was f

• Drawing on methods employed from political

  2018-11-05

  

  Drawing on methods employed from political sociology (Clayton & Pontusson, 1998), our study innovatively modeled the state-only family planning and abortion service expenditures both in per capita terms (per woman, age 15–44) and as fraction of total state spending. An additional strength is that ou

• There are several strengths and limitations of this research

  2018-11-05

  

  There are several strengths and limitations of this research that should be noted. Strengths of this research include objective measurement of physical activity and the unique study population. Physical activity was objectively collected using accelerometry, a validated method of assessing time spen

• The type of occupation of

  2018-11-05

  

  The type of occupation of an individual may influence the place of death. We found that Senexin A most of the adult deaths occurred among those with elementary occupations, closely followed by those in agricultural and fishery occupations. However, with the exception of the skilled agricultural/fis

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